In vivo molecular MRI of ICAM-1 expression in murine cardiac ischemia/reperfusion using a liposomal nanoparticle
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چکیده
liposomes, green: autofluorescence); (c) in vivo MRI 8h after reperfusion showed accumulation of anti-ICAM liposomes in infarct and infarct border zones 1.5h after liposome administration, confirmed by ex vivo CLSM. Bar=200μm. Figure 1: (a) Contrast agent optimization; (b) liposome binding to endothelial cells; (c) normalized cellular MR-relaxation rates; (d) liposome binding under shear stress. *=p<0.05 vs. IgG (a-c) or non-functionalized (d) liposomes, **=p<0.05 vs. all (Bonferroni). Data represent mean±SE (n=3-4). In vivo molecular MRI of ICAM-1 expression in murine cardiac ischemia/reperfusion using a liposomal nanoparticle
منابع مشابه
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